This seems promising - give it a try.

server { listen 80; server_name yourmublogs.com *.yourmublogs.com;

location / { root /home/yourmublogs/public_html; index index.html index.htm index.php; rewrite ^.*/files/(.*) /wp-content/blogs.php?file=$1;

if (!-e $request_filename) { rewrite ^.+?(/wp-.*) $1 last; rewrite ^.+?(/.*\.php)$ $1 last;

}

if ($query_string !~ ".*s=.*") { rewrite ^(.*) /wp-content/cache/supercache/$http_host/$1index.html; }

if ($http_cookie !~ "^.*comment_author_.*$" ) { rewrite ^(.*) /wp-content/cache/supercache/$http_host/$1index.html; }

if ($http_cookie !~ "^.*wordpressuser.*$" ) { rewrite ^(.*) /wp-content/cache/supercache/$http_host/$1index.html; }

if ($http_cookie !~ "^.*wp-postpass_.*$" ) { rewrite ^(.*) /wp-content/cache/supercache/$http_host/$1index.html break; }

error_page 404 = @tricky; } error_page 500 502 503 504 /50x.html; location = /50x.html { root html; }

location @tricky { rewrite ^ /index.php last; fastcgi_pass 127.0.0.1:8095; fastcgi_index index.php; fastcgi_param SCRIPT_FILENAME /home/yourmublogs/public_html$fastcgi_script_name; include /usr/local/nginx/conf/fastcgi_params; }

location ~ \.php$ { fastcgi_pass 127.0.0.1:8095; fastcgi_index index.php; fastcgi_param SCRIPT_FILENAME /home/yourmublogs/public_html$fastcgi_script_name; include /usr/local/nginx/conf/fastcgi_params; } }